NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation. In addition, NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells.
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The NF-kappaB transcription factor is normally transiently activated by proinflammatory cytokines and bacterial lipopolysaccharide (LPS); however, persistent NF-kappaB activation is commonly observed in inflammatory disease and malignancy. The ubiquitin editing enzyme A20 serves an essential role in … NF-κB is the key player in the regulation of inflammation, and its dysregulation in cancer is well studied [87]. NF-κB regulates the G1/S transition of HeLa cells during proliferation or inhibits invasiveness and proliferation of breast cancer cells [88,89]. Hence, efforts have been directed toward developing inhibitors of NF … NF-κB induces the expression of various pro-inflammatory genes, including those encoding cytokines and chemokines, and also participates in inflammasome regulation.
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